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Kazuhiko Takehara Selected Research

Arthus Reaction

9/2012Basophils and mast cells play critical roles for leukocyte recruitment in IgE-mediated cutaneous reverse passive Arthus reaction.
6/2009Establishment of experimental eosinophilic vasculitis by IgE-mediated cutaneous reverse passive arthus reaction.
5/2007Intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 cooperatively contribute to the cutaneous Arthus reaction.
12/2004Role of C-C chemokine receptors 1 and 5 and CCL3/macrophage inflammatory protein-1alpha in the cutaneous Arthus reaction: possible attenuation of their inhibitory effects by compensatory chemokine production.
8/2004P-selectin glycoprotein ligand-1 is required for the development of cutaneous vasculitis induced by immune complex deposition.
5/2003Relative contributions of selectins and intercellular adhesion molecule-1 to tissue injury induced by immune complex deposition.
3/2002The cutaneous reverse Arthus reaction requires intercellular adhesion molecule 1 and L-selectin expression.

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Kazuhiko Takehara Research Topics

Disease

67Systemic Scleroderma (Systemic Sclerosis)
01/2021 - 06/2002
37Fibrosis (Cirrhosis)
12/2021 - 06/2002
19Dermatomyositis (Dermatopolymyositis)
01/2021 - 04/2003
13Sclerosis
05/2019 - 06/2002
12Pulmonary Fibrosis (Fibrosing Alveolitis)
01/2017 - 11/2002
10Neoplasms (Cancer)
01/2019 - 10/2004
10Systemic Lupus Erythematosus (Libman-Sacks Disease)
05/2011 - 04/2003
9Melanoma (Melanoma, Malignant)
01/2021 - 09/2003
9Hemorrhage
01/2021 - 03/2002
8Myositis (Idiopathic Inflammatory Myopathies)
07/2021 - 02/2012
8Interstitial Lung Diseases (Interstitial Lung Disease)
01/2021 - 12/2010
8Inflammation (Inflammations)
01/2019 - 03/2002
8Autoimmune Diseases (Autoimmune Disease)
06/2017 - 02/2007
7Arthus Reaction
09/2012 - 03/2002
6Bullous Pemphigoid (Pemphigoid)
03/2021 - 06/2004
6Bronchiolitis Obliterans Syndrome
02/2020 - 12/2012
6Ulcer
06/2015 - 11/2004
5Connective Tissue Diseases (Connective Tissue Disease)
11/2020 - 10/2005
5Cicatrix (Scar)
08/2020 - 06/2004
5Localized Scleroderma (Morphea)
08/2019 - 01/2003
5Edema (Dropsy)
07/2019 - 03/2002
5Atopic Dermatitis (Atopic Eczema)
06/2007 - 04/2003
4digital ulcers
01/2017 - 06/2009
4Pulmonary Arterial Hypertension
09/2015 - 01/2006
4Rheumatoid Arthritis
09/2013 - 02/2007
4Wounds and Injuries (Trauma)
04/2013 - 03/2002
4Hypersensitivity (Allergy)
06/2010 - 04/2003
4Psoriasis (Pustulosis Palmaris et Plantaris)
03/2008 - 07/2003
4Contact Dermatitis (Eczema, Contact)
05/2007 - 04/2003
3Polymyositis
07/2020 - 05/2012
3Disease Progression
05/2019 - 11/2013
3Infections
09/2013 - 12/2005
3Diffuse Scleroderma (Progressive Systemic Sclerosis)
03/2013 - 04/2003
3Neoplasm Metastasis (Metastasis)
01/2012 - 09/2003
3Pemphigus (Pemphigus Vulgaris)
09/2007 - 06/2006
2Pruritus (Itching)
03/2021 - 10/2009
2Idiopathic Pulmonary Fibrosis
01/2021 - 11/2011
2Immune Complex Diseases (Immune Complex Disease)
07/2019 - 09/2012
2Mixed Connective Tissue Disease (MCTD)
02/2015 - 12/2007

Drug/Important Bio-Agent (IBA)

33AutoantibodiesIBA
07/2021 - 06/2002
21CytokinesIBA
01/2019 - 11/2002
12Immunoglobulin G (IgG)IBA
07/2019 - 04/2003
12EnzymesIBA
12/2016 - 04/2003
12Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
11/2014 - 03/2002
12Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)IBA
07/2014 - 03/2002
12L-SelectinIBA
07/2014 - 03/2002
11AntibodiesIBA
10/2018 - 11/2004
11ChemokinesIBA
01/2017 - 05/2004
9Bleomycin (Blenoxane)FDA LinkGeneric
12/2021 - 11/2002
9Proteins (Proteins, Gene)FDA Link
11/2020 - 04/2003
9ImmunosorbentsIBA
12/2016 - 04/2003
9Interleukin-6 (Interleukin 6)IBA
12/2012 - 06/2002
8AntigensIBA
01/2021 - 07/2005
8CollagenIBA
01/2013 - 04/2003
8Transforming Growth Factor beta (TGF-beta)IBA
11/2009 - 04/2003
7anti-scl-70 autoantibodiesIBA
08/2019 - 06/2004
7Connective Tissue Growth FactorIBA
11/2012 - 03/2002
6Biomarkers (Surrogate Marker)IBA
01/2020 - 05/2011
6Immunoglobulin E (IgE)IBA
09/2012 - 05/2004
6LigandsIBA
06/2010 - 08/2003
6P-SelectinIBA
06/2009 - 05/2003
5Antigen-Antibody Complex (Immune Complex)IBA
07/2019 - 08/2004
5Type I DNA Topoisomerases (Topoisomerase I)IBA
10/2018 - 01/2004
5Indicators and Reagents (Reagents)IBA
01/2014 - 09/2005
5Chemotactic FactorsIBA
04/2013 - 07/2003
5Immunoglobulin M (IgM)IBA
12/2012 - 01/2004
5Monoclonal AntibodiesIBA
11/2011 - 08/2004
5E-SelectinIBA
06/2009 - 05/2003
5SelectinsIBA
09/2007 - 05/2003
4Pharmaceutical PreparationsIBA
12/2020 - 12/2005
4trioctyl phosphine oxide (TOPO)IBA
08/2020 - 01/2004
4B-Cell Activating FactorIBA
12/2019 - 02/2007
4Interleukin-10 (Interleukin 10)IBA
01/2019 - 08/2008
4Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
12/2012 - 05/2005
3HLA Antigens (Human Leukocyte Antigens)IBA
07/2020 - 01/2016
3Sphingosine-1-Phosphate ReceptorsIBA
01/2019 - 09/2003
3Intravenous Immunoglobulins (IVIG)FDA Link
01/2019 - 04/2006
3Prednisolone (Predate)FDA LinkGeneric
01/2019 - 08/2004
3Bosentan (Tracleer)FDA Link
01/2017 - 07/2009
3Mi-2 antibodiesIBA
12/2016 - 12/2005
3InterferonsIBA
11/2014 - 02/2011
3Messenger RNA (mRNA)IBA
07/2014 - 07/2009
3Chemokine ReceptorsIBA
03/2013 - 07/2003
3Immunoglobulins (Immunoglobulin)IBA
12/2012 - 05/2009
3Transforming Growth Factors (Transforming Growth Factor)IBA
11/2012 - 01/2011
3Pulmonary Surfactant-Associated Protein D (Surfactant Protein D)IBA
05/2011 - 06/2004
3Fibroblast Growth Factor 2 (Basic Fibroblast Growth Factor)IBA
07/2009 - 03/2002
2RNA (Ribonucleic Acid)IBA
11/2020 - 02/2005
2ametantrone (HAQ)IBA
07/2020 - 06/2003
2transcriptional intermediary factor 1IBA
01/2020 - 12/2016
2Amino Acyl-tRNA Synthetases (Aminoacyl-tRNA Synthetase)IBA
12/2019 - 05/2007
2RNA Polymerase IIIIBA
10/2018 - 01/2017
2Anti-Idiotypic AntibodiesIBA
10/2018 - 11/2010
2anticentromere antibodyIBA
10/2018 - 08/2004
2beta-cyclodextrin tetradecasulfate (CTDS)IBA
12/2016 - 02/2015
2Acyclovir (Aciclovir)FDA LinkGeneric
06/2015 - 11/2007

Therapy/Procedure

11Therapeutics
05/2019 - 10/2003
3Injections
07/2009 - 05/2005
2Intradermal Injections
12/2021 - 09/2012
2Bone Marrow Transplantation (Transplantation, Bone Marrow)
01/2019 - 04/2017